Numerical
Analysis
Manu Jose Garcia-Aznar
Group of Structural Mechanics and Materials Modeling (GEMM)
Aragon Institute of Engineering Research
University of Zaragoza
Spain
Presenter at Delft Symposium on Mathematical Modeling of Wound Healing
Date: October 15, 2009. Location Pegasuszaal (Pegasus Lecture Room),
Kluyverweg 6, Delft University of Technology, Delft, the Netherlands.
Abstract
Mechanobiological modeling of bone regeneration
Bone tissue is a hierarchical structural composite material, with the ability to repair itself through different mechanisms. For example, when a bone is fractured bone tissue is able to repair it. And, bone is also able to update its shape and internal microstructure, even removing microdamage accumulated by fatigue and minimizing the risk of fracture. All these regenerative processes are regulated by the mechanical environment that bone tissue senses. The interaction between mechanical and biological factors is usually described through the concept of Mechanobiology that tries to predict the evolution of the mechanical and biological behaviour of tissues as consequence of the mechanical environment.
One way to understand mechanobiological effects is through computational modelling, which is complementary to traditional approaches of theory and experiment. In fact, computational simulation in mechanobiology presents many advantages: possibility of comparing many different conditions, factors and interactions (mechanical, biological, pharmacological, etc), simulations closer to reality in some cases due to the possibility of considering and controlling factors that cannot be controlled or measure in experimental tests, economical impact (low cost) and reduction of animal experiments.
In this work several mechanobiological examples of application in bone regeneration are presented: bone remodelling after prosthesis implantation, bone fracture healing, bone ingrowth and bone tissue engineering.
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Last modified: August 9, 2009, by Fred Vermolen